Prof. Dr. Bernhard Wünsch

Westfälische Wilhelms Universität Münster
Fachbereich: Chemie und Pharmazie
Zugeordnete Branche: Life Sciences und Gesundheit
Zugeordnetes Fachgebiet: Pharmazie

Institut: Institut für Pharmazeutische und Medizinische Chemie

Life Sciences

The main focus is the development and synthesis of novel ligands for receptors in the Central Nervous System.

Of particular interest are:

• NMDA-receptors (PCP-binding site, NR1B/2B-subunit)
• Opioid-receptors (mü, kappa and delta)
• sigma-receptor (sigma1 and sigma2)
• Neurokinin-receptors

Synthesis of novel ligands:

• Stereoselective synthesis (asymmetric synthesis, diastereoselective synthesis, chiral-pool-Synthesis)
• Application of enzymes for stereoselective synthesis

Receptor affinity:

• Determination of the receptor affinity by performing competition experiments with selective, tritium-labelled reference compounds (in vitro)
• Structure-affinity-relationships

Systematic optimization of the ligands:

• Molecular modelling

Westfälische Wilhelms Universität Münster
Corrensstraße 48 | 48149 Münster

Tel. 0251 - 83-33310

wuensch@uni-muenster.de

https://www.uni-muenster.de/Chemie.pz/forschen/ag/wuensch/

Chemie | Pharmazeutische Chemie | Nervensystem | Liganden | Rezeptoren | Molekulare Modellierung | Enzyme | Synthese